Influence of Cobalt on Fermentative Methylation
AUTOR(ES)
Claridge, C. A.
RESUMO
Streptomyces rishiriensis produces at least five closely related antibiotics. Strain selection yielded a culture producing only the most active component, coumermycin A. Hydrolysis of this antibiotic by barium hydroxide yielded both 5-methyl-pyrrole-2-carboxylic acid and pyrrole-2-carboxylic acid, which could be separated by paper chromatography. Coumermycin A was thus shown to be two fractions, designated A1 and A2 depending upon the nature of the pyrrole carboxylic acid portion. The addition of cobalt to the fermentation medium at a level as low as 0.01 μg/ml shifted the fermentation exclusively to the production of coumermycin A1. Other ions were ineffective, except nickel, whose activity could be explained by the presence of contaminating cobalt.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=546669Documentos Relacionados
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