Influenza A Virus-Infected Hosts Boost an Invasive Type of Streptococcus pyogenes Infection in Mice

AUTOR(ES)

Okamoto, Shigefumi

FONTE

American Society for Microbiology

RESUMO

The apparent worldwide resurgence of invasive Streptococcus pyogenes infection in the last two decades remains unexplained. At present, animal models in which toxic shock-like syndrome or necrotizing fasciitis is induced after S. pyogenes infection are not well developed. We demonstrate here that infection with a nonlethal dose of influenza A virus 2 days before intranasal infection with a nonlethal dose of S. pyogenes strains led to a death rate of more than 90% in mice, 10% of which showed necrotizing fasciitis. Infection of lung alveolar epithelial cells by the influenza A virus resulted in viral hemagglutinin expression on the cell surface and promoted internalization of S. pyogenes. However, treatment with monoclonal antibodies to hemagglutinin markedly decreased this internalization. Our results indicate that prior infection with influenza A virus induces a lethal synergism, resulting in the induction of invasive S. pyogenes infection in mice.

Documentos Relacionados

• Interleukin-4 causes delayed virus clearance in influenza virus-infected mice.
• Inhibition of influenza virus production in virus-infected mice by RNA interference
• Fibrinogen-mediated adherence of group A Streptococcus to influenza A virus-infected cell cultures.
• Appearance of Rosette-Forming Macrophages in the Lungs of Influenza Virus-Infected Mice
• Lymphocyte cytotoxicity to influenza virus-infected cells: response to vaccination and virus infection.