Inhibition by Exogenous Interferon of Replication of Poliovirus Ribonucleic Acid in Chick Brain
AUTOR(ES)
Youngner, Julius S.
RESUMO
Youngner, Julius S. (University of Pittsburgh, Pittsburgh, Pa.), and Marion E. Kelly. Inhibition by exogenous interferon of replication of poliovirus ribonucleic acid in chick brain. J. Bacteriol. 90:443–445. 1965.—The replication of poliovirus was studied after the intracerebral inoculation of infectious ribonucleic acid (RNA) into the brains of 2-day-old chicks; these animals are not susceptible to intact virus. Single-cycle replication of virus, which reached a peak in about 12 hr, was completely inhibited by prior intraperitoneal injection of interferon prepared from the allantoic fluid of chick embryos infected with influenza virus. A single dose of as little as 500 units of interferon, measured by a plaque-reduction method, completely suppressed viral replication when injected 24 hr prior to infectious RNA. This system provides a model for the study of the protection of target organs by passively transferred interferon injected at a distance.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=315664Documentos Relacionados
- Assay of Chick Interferons by the Inhibition of Viral Ribonucleic Acid Synthesis
- Quantitative Aspects of Inhibition of Virus Replication by Interferon in Chick Embryo Cell Cultures
- Inhibition of deoxyribonucleic acid replication in Bacillus brevis by ribonucleic acid polymerase inhibitors.
- Inhibition of Replication of Ribonucleic Acid Bacteriophage f2 by Superinfection with Bacteriophage T4
- Inhibition of Early Vaccinia Virus Ribonucleic Acid Synthesis in Interferon-Treated Chicken Embryo Fibroblasts