Inhibition of 3-Deoxy-d-Arabinoheptulosonic Acid-7-Phosphate Synthetase (trp) in Escherichia coli
AUTOR(ES)
Pittard, J.
RESUMO
The growth of a strain of Escherichia coli K-12 which possesses only the single isoenzyme 3-deoxy-d-arabinoheptulosonic acid-7-phosphate (DAHP) synthetase (trp), and which makes this enzyme constitutively, is inhibited by tryptophan. The accumulation of DAHP by a derivative of this strain unable to convert DAHP to dehydroquinate is also inhibited by tryptophan. The enzymic activity of DAHP synthetase (trp) in the presence of CO2+ is sensitive to inhibition by tryptophan. Mutant strains of E. coli have been isolated in which DAHP synthetase (trp) is feedback-resistant.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=249841Documentos Relacionados
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