Inhibition of CD1 Expression in Human Dendritic Cells during Intracellular Infection with Leishmania donovani

AUTOR(ES)

Amprey, Joseph L.

FONTE

American Society for Microbiology

RESUMO

Dendritic cells can initiate antimicrobial responses by CD1-mediated presentation of pathogen-derived glycolipids. We show that the protozoan Leishmania donovani inhibits CD1 expression and prevents activation of CD1-restricted T cells by dendritic cells. Evasion of presentation by CD1 may represent a Leishmania survival strategy to avoid recognition of abundant parasite glycolipids.

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