Inhibition of Host Protein Synthesis and Degradation of Cellular mRNAs During Infection by Influenza and Herpes Simplex Virus
AUTOR(ES)
Inglis, S. C.
RESUMO
Cloned DNA copies of two cellular genes were used to monitor, by blot hybridization, the stability of particular cell mRNAs after infection by influenza virus and herpesvirus. The results indicated that the inhibition of host cell protein synthesis that accompanied infection by each virus could be explained by a reduction in the amounts of cellular mRNAs in the cytoplasm, and they suggested that this decrease was due to virus-mediated mRNA degradation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=369973Documentos Relacionados
- Degradation of cellular mRNAs induced by a virion-associated factor during herpes simplex virus infection of Vero cells.
- The UL41 protein of herpes simplex virus mediates selective stabilization or degradation of cellular mRNAs
- Degradation of cellular mRNA during infection by herpes simplex virus.
- Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway
- Differential stability of host mRNAs in Friend erythroleukemia cells infected with herpes simplex virus type 1.
