Inhibition of lipopolysaccharide-initiated activation of serum complement by polymyxin B.

AUTOR(ES)
RESUMO

Treatment of bacterial lipopolysaccharides (endotoxins) isolated from Salmonella minnesota R595 or purified lipid A with the antibiotic polymyxin B has been demonstrated to abrogate the ability of these molecules to activate serum complement. The inhibition is a function of the ratio of polymyxin B to lipopolysaccharide.

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