Inhibition of Platelet Function by Sulbenicillin and Its Metabolite
AUTOR(ES)
Ikeda, Yasuo
RESUMO
The effect of sulbenicillin and its major metabolite, α-sulfobenzylpenicilloic acid, on platelet function was investigated. Sulbenicillin caused inhibition of platelet aggregation and release reaction in the same manner as carbenicillin. α-Sulfobenzylpenicilloic acid was found to cause much stronger inhibition of platelet function. The results indicate that the strong inhibitory action of α-sulfobenzylpenicilloic acid may also take part in impaired platelet functions following administration of sulbenicillin to humans.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=352348Documentos Relacionados
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