Inhibition of Ribonucleic Acid Synthesis by Nalidixic Acid in Escherichia coli
AUTOR(ES)
Javor, George T.
RESUMO
The effect of low concentrations of nalidixic acid on ribonucleic acid (RNA) synthesis in Escherichia coli was examined. It was observed that RNA synthesis in exponentially growing cells was not significantly affected, in harmony with previous studies. However, RNA synthesis was markedly depressed by nalidixic acid during starvation for an amino acid or during chloramphenicol treatment. This effect was not caused by increased killing or inhibition of nucleoside triphosphate synthesis by nalidixic acid. The pattern of radioactive uracil incorporation into transfer RNA or ribosomes was not changed by the drug. The sensitivity of RNA synthesis to nalidixic acid in the absence of protein production may be useful in probing the amino acid control of RNA synthesis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=245761Documentos Relacionados
- Inhibition of Messenger Ribonucleic Acid Synthesis in Escherichia coli by Thiolutin
- Induction of Excessive Deoxyribonucleic Acid Synthesis in Escherichia coli by Nalidixic Acid
- Mechanism of Action of Nalidixic Acid on Escherichia coli II. Inhibition of Deoxyribonucleic Acid Synthesis
- Transient growth inhibition of Escherichia coli K-12 by ion chelators: "in vivo" inhibition of ribonucleic acid synthesis.
- Messenger Ribonucleic Acid Synthesis and Degradation in Escherichia coli During Inhibition of Translation