INHIBITION OF THE GROWTH OF AGENTS OF THE PSITTACOSIS GROUP BY d-CYCLOSERINE AND ITS SPECIFIC REVERSAL BY d-ALANINE1
AUTOR(ES)
Moulder, James W.
RESUMO
Moulder, James W. (University of Chicago, Chicago, Ill.), Dorothy L. Novosel, and Julius E. Officer. Inhibition of the growth of agents of the psittacosis group by d-cycloserine and its specific reversal by d-alanine. J. Bacteriol. 85:707–711. 1963.—d-Cycloserine inhibited multiplication of four members of the psittacosis group in chick embryo yolk sac. d-Alanine reversed each inhibition. In infections with the agent of mouse pneumonitis, the most sensitive member of the psittacosis group tested, d-alanine competitively antagonized the growth inhibition produced by d-cycloserine. Of a number of other potential reversing agents, only dl-alanyl-dl-alanine reversed the effect of d-cycloserine on mouse pneumonitis agent. The significance of the susceptibility of the psittacosis group to d-cycloserine is discussed in light of the known mode of action of this antibiotic on bacteria.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=278204Documentos Relacionados
- ANTAGONISM OF d-CYCLOSERINE INHIBITION OF MYCOBACTERIAL GROWTH BY d-ALANINE
- REVERSAL OF d-CYCLOSERINE INHIBITION OF BACTERIAL GROWTH BY ALANINE
- Mechanism of d-Cycloserine Action: Transport Systems for d-Alanine, d-Cycloserine, l-Alanine, and Glycine1
- Mechanism of d-Cycloserine Action: Transport Mutants for d-Alanine, d-Cycloserine, and Glycine1
- Overexpression of the D-alanine racemase gene confers resistance to D-cycloserine in Mycobacterium smegmatis.
