Inhibition of Vitamin K2 and Carotenoid Synthesis in Staphylococcus aureus by Diphenylamine

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RESUMO

Diphenylamine at concentrations which did not effect the growth rate inhibited the synthesis of vitamin K2 in both anaerobic and aerobic cultures by about 50%. At this concentration, diphenylamine inhibited the synthesis of the cyclic carotenoids δ-carotene and the rubixanthins 25 to 35% anaerobically and 60 to 90% aerobically. The inhibition of synthesis of cyclic carotenoids and vitamin K2 by diphenylamine had no detectable effect on the formation of the membrane-bound electron transport system.

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