Insig: a significant integrator of nutrient and hormonal signals

AUTOR(ES)

Attie, Alan D.

FONTE

American Society for Clinical Investigation

RESUMO

Lipogenesis is regulated by sterols and by insulin through the regulated expression and activation of the sterol regulatory element–binding proteins (SREBPs). A new study shows one way in which sterol and insulin regulation can be decoupled. In transgenic mice overexpressing a protein that regulates SREBP activation, lipogenesis is more sensitive to cholesterol and less sensitive to insulin.

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