Interaction of hemoglobin with three ligans: organic phosphates and the Bohr effect.

AUTOR(ES)

Benesch, R E

RESUMO

The assumption that the Bohy coefficient (less than log p 50)/(less than pH) is equal to the haldane coefficient (less than h minus plus) of hemoglobin is shown to be incorrect in the presence of allosteric effectors such as 2,3-diphosphoglycerate. The theoretical relation between the two coefficients in the presence of 2.3-diphosphoglycerate as derived. Experimental data on the variation of both coefficients with diphosphoglycerate concentration are presented and shown to be in agreement with prediction.

Documentos Relacionados

• Linearity of the hemoglobin oxidation bohr effect.
• Interaction of gentamicin with the A band and B band lipopolysaccharides of Pseudomonas aeruginosa and its possible lethal effect.
• Structure of deoxyhemoglobin Cowtown [His HC3(146) beta----Leu]: origin of the alkaline Bohr effect and electrostatic interactions in hemoglobin.
• Bacterial biofilms and the bioelectric effect.
• Effect of altitude on oxygen binding by hemoglobin and on organic phosphate levels