Interaction of Human Immunodeficiency Virus Type 2 Vpx and Invariant Chain
AUTOR(ES)
Pancio, Heather A.
FONTE
American Society for Microbiology
RESUMO
Vpx is a virion-associated protein of human immunodeficiency virus type 2 (HIV-2) and simian immunodeficiency viruses. The yeast two-hybrid system was used to identify invariant chain (Ii) as a cellular protein that interacts with HIV-2 Vpx. Vpx-Ii interaction was confirmed in cell-free reactions using bacterially expressed glutathione S-transferase fusion proteins and by coimmunoprecipitation in transfected and infected cells. In chronically infected cells expressing Vpx, Ii levels were markedly decreased, presumably due to enhanced degradation. These findings suggest that Vpx may disrupt major histocompatibility complex class II antigen presentation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=112116Documentos Relacionados
- Human Immunodeficiency Virus Type 2 Vpx-Gag Interaction
- Dispensable role of the human immunodeficiency virus type 2 Vpx protein in viral replication.
- Localization of the Vpx packaging signal within the C terminus of the human immunodeficiency virus type 2 Gag precursor protein.
- Zeta Chain of the T-Cell Receptor Interacts with nef of Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2
- Cross-neutralization of human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus isolates.
