Interleukin-10 and Pathogenesis of Murine Ocular Toxoplasmosis
AUTOR(ES)
Lu, Fangli
FONTE
American Society for Microbiology
RESUMO
To understand the role of interleukin-10 (IL-10) in ocular toxoplasmosis, we compared C57BL/6 (B6) and BALB/c background mice lacking a functional IL-10 gene (IL-10−/−) and B6 transgenic mice expressing IL-10 under the control of the IL-2 promoter. Increased cellular infiltration and necrosis were observed in the eye tissue of IL-10−/− mice of both the B6 and BALB/c backgrounds with associated changes in the levels of cytokines in serum. In contrast, there was no evidence of necrosis in the eye tissue from IL-10 transgenic mice following parasite exposure. Our results demonstrate that IL-10 is important in the regulation of inflammation during acute ocular toxoplasmosis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=308941Documentos Relacionados
- CD4+ T Cells in the Pathogenesis of Murine Ocular Toxoplasmosis
- Toxoplasma gondii and ocular toxoplasmosis: pathogenesis.
- Interleukin-10 (IL-10) Counterregulates IL-4-Dependent Effector Mechanisms in Murine Filariasis
- Dual Role of Interleukin-10 in Murine Lyme Disease: Regulation of Arthritis Severity and Host Defense
- Pancreatic islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction.