Intracellular multiplication of leprosy-derived mycobacteria in Schwann cells of dorsal root ganglion cultures.

AUTOR(ES)

Mukherjee, R

RESUMO

Organized nerve cultures of dorsal root ganglia from neonatal mice were infected with Mycobacterium leprae, the causative agent of leprosy. A significant multiplication of the acid-fast bacilli was observed within the Schwann cell component of the culture. The growth of these bacilli was sensitive to antileprosy drugs and was not observed directly in bacteriological media. These organisms were brightly stained with the monoclonal antibody to phenolic glycolipid-I, a M. leprae-specific marker. The antigenic, pathogenic, and biochemical characteristics of this mycobacterium are under investigation.

Documentos Relacionados

• Primary structure of the wall peptidoglycan of leprosy-derived corynebacteria.
• Control of action potential propagation by intracellular Ca2+ in cultured rat dorsal root ganglion cells.
• In vivo effect of brain-derived neurotrophic factor on the survival of developing dorsal root ganglion cells.
• Ultrastructural Study of Long-Term Measles Infection in Cultures of Hamster Dorsal-Root Ganglion
• Multiplication of measles virus in cell cultures.