Intratracheal Injection into Rats of Size-graded Silica Particles

AUTOR(ES)

Goldstein, B.

RESUMO

An experiment is described in which suspensions of size-graded silica particles of less than 1 μ, 1 to 3 μ, and 2 to 5 μ nominal size ranges and of equal surface area (600 sq. cm./ml.) were injected intratracheally into rats. After four months the rats were killed and the lungs were examined histologically for the grade of fibrosis and chemically for the silica and collagen content.

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