Involvement of spectrin in membrane fusion: induction of fusion in human erythrocyte ghosts by proteolytic enzymes and its inhibition by antispectrin antibody.
AUTOR(ES)
Lalazar, A
RESUMO
In contrast to intact human erythrocytes, human erythrocyte ghosts can be agglutinated but not fused by Sendai virus. Membrane fusion can, however, be induced in virus-agglutinated erythrocyte ghosts by addition of proteolytic enzymes such as trypsin, papain, or Pronase. When erythrocyte ghosts were reacted with antispectrin antiserum, the antiserum inhibited both the induction of fusion and the proteolysis of the membrane spectrin. The correlation between the membrane fusion process and the membrane cytoskeleton is discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=382930Documentos Relacionados
- Participation of spectrin in Sendai virus-induced fusion of human erythrocyte ghosts.
- Effect of anti-spectrin antibody and ATP on deformability of resealed erythrocyte membranes.
- Membrane ultrastructural changes during calcium phosphate-induced fusion of human erythrocyte ghosts.
- The hemifusion intermediate and its conversion to complete fusion: regulation by membrane composition.
- Energized endocytosis in human erythrocyte ghosts.