Iron Acquisition from Pseudomonas aeruginosa Siderophores by Human Phagocytes: an Additional Mechanism of Host Defense through Iron Sequestration?

AUTOR(ES)

Britigan, Bradley E.

FONTE

American Society for Microbiology

RESUMO

Chelation of iron to iron-binding proteins is a strategy of host defense. Some pathogens counter this via the secretion of low-molecular-weight iron-chelating agents (siderophores). Human phagocytes possess a high-capacity mechanism for iron acquisition from low-molecular-weight iron chelates. Efficient acquisition and sequestration of iron bound to bacterial siderophores by host phagocytes could provide a secondary mechanism to limit microbial access to iron. In the present work we report that human neutrophils, macrophages, and myeloid cell lines can acquire iron from the two Pseudomonas aeruginosa siderophores. Analogous to iron acquisition from other low-molecular-weight chelates, iron acquisition from the siderophores is ATP independent, induced by multivalent cationic metals, and unaffected by inhibitors of endocytosis and pinocytosis. In vivo, this process could serve as an additional mechanism of host defense to limit iron availability to invading siderophore-producing microbes.

Documentos Relacionados

• Burkholderia spp. Alter Pseudomonas aeruginosa Physiology through Iron Sequestration
• Siderophore-mediated iron acquisition from transferrin by Pseudomonas aeruginosa.
• Kinetics of iron acquisition from ferric siderophores by Paracoccus denitrificans.
• Utilization of Microbial Siderophores in Iron Acquisition by Oat 1
• Sertoli cells as phagocytes: an electron microscopic study.