Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells.

AUTOR(ES)

Holtzman, D A

RESUMO

We have isolated a murine cDNA that shares extensive homology with genes encoding the src (Rous sarcoma virus oncogene)-related family of protein-tyrosine kinases. The cDNA includes an open reading frame of 1509 base pairs, and conceptual translation predicts a protein of 56 kDa. Blot-hybridization analysis indicates that this src-related gene is expressed in normal macrophages and in cell lines representing both the myeloid and lymphoid B-cell lineages and, accordingly, is designated "bmk" (B cell/myeloid kinase). In addition, bmk mRNA levels increase following the induced differentiation of the murine myelomonocytic leukemic cell line WEHI-3B.

Documentos Relacionados

• Acquisition of transforming properties by FYN, a normal SRC-related human gene.
• Structure and expression of STK, a src-related gene in the simple metazoan Hydra attenuata.
• Maternal inheritance of transcripts from three Drosophila src-related genes.
• Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.
• Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells.