Isoprenoid biosynthesis in the erythrocytic stages of Plasmodium falciparum

AUTOR(ES)

Jordão, Fabiana Morandi, Kimura, Emília Akemi, Katzin, Alejandro Miguel

FONTE

Memórias do Instituto Oswaldo Cruz

DATA DE PUBLICAÇÃO

2011-08

RESUMO

The development of new drugs is one strategy for malaria control. Biochemical pathways localised in the apicoplast of the parasite, such as the synthesis of isoprenic precursors, are excellent targets because they are different or absent in the human host. Isoprenoids are a large and highly diverse group of natural products with many functions and their synthesis is essential for the parasite's survival. During the last few years, the genes, enzymes, intermediates and mechanisms of this biosynthetic route have been elucidated. In this review, we comment on some aspects of the methylerythritol phosphate pathway and discuss the presence of diverse isoprenic products such as dolichol, ubiquinone, carotenoids, menaquinone and isoprenylated proteins, which are biosynthesised during the intraerythrocytic stages of Plasmodium falciparum.

Documentos Relacionados

• Initial extracellular development in vitro of erythrocytic stages of malaria parasites (Plasmodium falciparum).
• Extracellular (axenic) development in vitro of the erythrocytic cycle of Plasmodium falciparum.
• Glucan-Enhanced Immunogenicity of Killed Erythrocytic Stages of Plasmodium berghei
• Serial Analysis of Gene Expression in Plasmodium falciparum Reveals the Global Expression Profile of Erythrocytic Stages and the Presence of Anti-Sense Transcripts in the Malarial Parasite
• Biossíntese de vitamina E nos estágios intraeritrocitários de P. falciparum.