Laboratory and wild-derived mice with multiple loci for production of xenotropic murine leukemia virus.
AUTOR(ES)
Kozak, C A
RESUMO
Mendelian segregation analysis was used to define genetic loci for the induction of infectious xenotropic murine leukemia virus in several laboratory and wild-derived mice. MA/My mice contain two loci for xenotropic virus inducibility, one of which, Bxv -1, is the only induction locus carried by five other inbred strains. The second, novel MA/My locus, designated Mxv -1, is unlinked to Bxv -1 and shows a lower efficiency of virus induction. The NZB mouse carries two induction loci; both are distinct from Bxv -1 since neither is linked to the Pep-3 locus on chromosome 1. Finally, one partially inbred strain derived from the wild Japanese mouse, Mus musculus molossinus, carries multiple (at least three) unlinked loci for induction of xenotropic virus. Although it is probable that inbred strains inherited xenotropic virus inducibility from Japanese mice, our data suggest that none of the induction loci carried by this particular M. m. molossinus strain are allelic with Bxv -1.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=254402Documentos Relacionados
- Analysis of wild-derived mice for Fv-1 and Fv-2 murine leukemia virus restriction loci: a novel wild mouse Fv-1 allele responsible for lack of host range restriction.
- Identification of two cerebral malaria resistance loci using an inbred wild-derived mouse strain
- Electrophoretic Variation for X Chromosome-Linked Hypoxanthine Phosphoribosyl Transferase (Hprt) in Wild-Derived Mice
- Variation in the Major Urinary Protein Multigene Family in Wild-Derived Mice
- Wild-derived inbred mouse strains have short telomeres