Lack of airborne spread of infection by Legionella pneumophila among guinea pigs.
AUTOR(ES)
Katz, S M
RESUMO
Many investigators find no spread of Legionnaires disease from person to person. The present study examined the question of airborne transmission of infection by Legionella pneumophila serogroup 1 from guinea pigs inoculated nasally with the agent to healthy guinea pigs. The nasal inoculation produced confluent peribronchiolar pneumonia similar to the pulmonary lesions observed in humans, but by techniques of clinical observation, serology, culture, and pathology, there was no evidence of airborne spread of infection from 26 inoculated guinea pigs to 64 uninoculated guinea pigs. The results, compatible with epidemiological studies of Legionnaires disease that fail to demonstrate airborne person-to-person transmission of the illness in humans, are useful for scientists who work with animal models of Legionnaires disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=347784Documentos Relacionados
- Susceptibility of Legionella pneumophila to ofloxacin in vitro and in experimental Legionella pneumonia in guinea pigs.
- Macrophage-activating T-cell factor(s) produced in an early phase of Legionella pneumophila infection in guinea pigs.
- Fate of Legionella pneumophila Philadelphia-1 strain in resident, elicited, activated, and immune peritoneal macrophages of guinea pigs.
- Antimicrobial therapy of experimental Legionella micdadei pneumonia in guinea pigs.
- Vaccination against Legionella pneumophila: serum antibody correlates with protection induced by heat-killed or acetone-killed cells against intraperitoneal but not aerosol infection in guinea pigs.