Leigh's disease: significance of the biochemical changes in brain.
AUTOR(ES)
Murphy, J V
RESUMO
Analysis of five brains from patients with Leigh's disease demonstrates an accumulation of thiamine pyrophosphate and a deficiency of thiamine triphosphate. The enzyme which converts thiamine pyrophosphate to thiamine triphosphate was normally active in two of these brains, suggesting that the inhibitor found in Leigh's disease is probably producing the observed neurochemical changes. Reasons for the histological similarity between Leigh's and Wernicke's diseases are suggested.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=492163Documentos Relacionados
- Adult form of Leigh's disease: a clinico pathological case with CT scan examination.
- Necrotising haemorrhagic encephalomyelopathy in an adult: Leigh's disease.
- Necrotising hemorrhagic encephalopathy in an adult: Leigh's disease?
- Shy1p is necessary for full expression of mitochondrial COX1 in the yeast model of Leigh’s syndrome
- Benzodiazepine receptors mediate regional blood flow changes in the living human brain.