Lentiviruses are naturally resident in a latent form in long-term ovine fibroblast cultures.
AUTOR(ES)
Barban, V
RESUMO
Long-term ovine fibroblast cultures contain replicative-competent lentiviruses in a latent form. This in vitro phenomenon, never described previously for lentiviruses, was clearly demonstrated by activating the expression of latent viruses with various inducing cell treatments, some of which were efficient in inducing endogenous retroviruses or latent herpesviruses. Activated lentiviruses were highly lytic in ovine fibroblasts (type I), or they established persistent infections (type II) as described previously for field isolates from sheep with progressive pneumonia (Quérat et al., J. Virol. 52:671-678, 1984).
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=254573Documentos Relacionados
- Osteoclast-like cells form in long-term human bone marrow but not in peripheral blood cultures.
- Evidence for structured variation in self-renewal capacity within long-term bone marrow cultures.
- Unregulated proliferation of primitive neoplastic progenitor cells in long-term polycythemia vera marrow cultures.
- Atypical multinucleated cells form in long-term marrow cultures from patients with Paget's disease.
- Transforming growth factor beta inhibits formation of osteoclast-like cells in long-term human marrow cultures.