Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
AUTOR(ES)
Petersen, Kitt Falk
FONTE
American Society for Clinical Investigation
RESUMO
Lipodystrophy is a rare disorder that is characterized by selective loss of subcutaneous and visceral fat and is associated with hypertriglyceridemia, hepatomegaly, and disordered glucose metabolism. It has recently been shown that chronic leptin treatment ameliorates these abnormalities. Here we show that chronic leptin treatment improves insulin-stimulated hepatic and peripheral glucose metabolism in severely insulin-resistant lipodystrophic patients. This improvement in insulin action was associated with a marked reduction in hepatic and muscle triglyceride content. These data suggest that leptin may represent an important new therapy to reverse the severe hepatic and muscle insulin resistance and associated hepatic steatosis in patients with lipodystrophy.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=150981Documentos Relacionados
- Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice
- Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat.
- Hepatic subcapsular steatosis in a patient with insulin dependent diabetes receiving dialysis.
- Impaired glucose phosphorylation and transport in skeletal muscle cause insulin resistance in HIV-1–infected patients with lipodystrophy
- Unbuckling lipodystrophy from insulin resistance and hypertension