Leukemia-Specific DNA Sequences in Leukocytes of the Leukemic Member of Identical Twins
AUTOR(ES)
Baxt, W.
RESUMO
The discovery in human leukemic cells of particulate elements encapsulating 70S RNA and RNA-directed DNA polymerase made possible the synthesis of a [3H]DNA probe that could detect leukemia-specific sequences in the DNA of normal and leukemic individuals. In an earlier study of a series of unrelated leukemic patients, we established that the nuclear DNA of their leukemic cells contain particle-related sequences that cannot be detected in leukocytes of normal individuals. This result is inconsistent with the virogene concept that demands the inclusion of one complete copy of oncogenic information in the genome of every normal cell.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=427070Documentos Relacionados
- Isolation and Identification of Lymphocytic and Myelogenous Leukemia-Specific Sequences in Genomes of Gibbon Oncornaviruses
- Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro.
- Cell death induction by the acute promyelocytic leukemia-specific PML/RARα fusion protein
- Chronic myelogenous leukemia shapes host immunity by selective deletion of high-avidity leukemia-specific T cells
- Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.
