Light Chain Sequences of Human IgM Cold Agglutinins
AUTOR(ES)
Capra, J. Donald
RESUMO
The amino-terminal amino-acid sequence has been determined for the kappa light chains of nine IgM cold agglutinins with specificity for blood group-related carbohydrate antigens. Six of the nine sequences corresponded to the prototype VKIII subgroup pattern, two to that of subgroup VKII, and only one to the VKI subgroup. This distribution of kappa subgroups differs markedly from that of normal and myeloma proteins sequenced to date, where the VKI subgroup is more prevalent than either VKII or VKIII. Evidence is presented that supports the conclusion that the unusual subgroup distribution relates to the antibody property itself and not to some other attribute of these molecules.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=427540Documentos Relacionados
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