Limited Role for Interleukin-18 in the Host Protection Response to Pulmonary Infection with Pseudomonas aeruginosa in Mice
AUTOR(ES)
Nakasone, Chikara
FONTE
American Society for Microbiology
RESUMO
We report that clearance of Pseudomonas aeruginosa, accumulation of neutrophils, and synthesis of tumor necrosis factor alpha and macrophage inflammatory protein 2 in the infected lung were not largely different in interleukin-18 (IL-18) knockout or transgenic mice compared with control mice. Our results suggest a limited role for IL-18 in the host defense against P. aeruginosa.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=517573Documentos Relacionados
- Interleukin-18 Impairs the Pulmonary Host Response to Pseudomonas aeruginosa
- Limited Interleukin-18 Response in Salmonella-Infected Murine Macrophages and in Salmonella-Infected Mice
- Role of Interleukin-18 in Host Defense against Disseminated Candida albicans Infection
- Role of Interleukin-18 (IL-18) in Mycobacterial Infection in IL-18-Gene-Disrupted Mice
- Interleukin-18 Facilitates the Early Antimicrobial Host Response to Escherichia coli Peritonitis
