Lipoprotein composition and serum Lp(a) lipoprotein in hypobetalipoproteinaemia.

AUTOR(ES)

Crook, M

RESUMO

A family with hypobetalipoproteinaemia was studied to examine the Lp(a) lipoprotein, lipoprotein cholesterol, and triglyceride composition of the serum lipids. Lp(a) lipoprotein was measured by immunoassay. Serum lipoproteins were separated by ultracentrifugation. Cholesterol and triglycerides were measured using standard enzymatic assays. Serum apolipoprotein B was low and Lp(a) undetectable in the index patient and in her father and son. Separation of the lipoproteins by ultracentrifugation showed a low cholesterol content of serum low density lipoprotein in the affected family members and also a low triglyceride content of high density lipoprotein particles in two affected members. It is concluded that serum lipoprotein cholesterol is altered in hypobetalipoproteinaemia, and family members of index cases have undetectable serum Lp(a) lipoprotein concentrations.

Documentos Relacionados

• Increased concentrations of serum Lp(a) lipoprotein in patients with primary gout.
• Serum Lp(a) lipoprotein concentration and outcome of thrombolytic treatment for myocardial infarction.
• Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a)-lipoprotein concentrations in plasma.
• Sib-pair analysis detects elevated Lp(a) levels and large variation of Lp(a) concentration in subjects with familial defective ApoB.
• The atherogenic lipoprotein Lp(a) is internalized and degraded in a process mediated by the VLDL receptor.