Loss of transformed phenotype upon senescence of Rous sarcoma virus-infected chicken neuroretinal cells.
AUTOR(ES)
Seigel, G M
RESUMO
Success in obtaining permanent Rous sarcoma virus-infected chicken cell lines has been limited because of a senescence phenomenon. We show that a diminished, transformed phenotype, followed by dramatic morphological changes, precedes senescence. These changes are associated with continued expression of pp60v-src, as well as specific alterations in expression of two possible phosphorylated substrates of pp60v-src.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=283681Documentos Relacionados
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