Low biological activity of Helicobacter pylori lipopolysaccharide.
AUTOR(ES)
Muotiala, A
RESUMO
Lipopolysaccharide from the gastroduodenal pathogen Helicobacter pylori was tested for its ability to induce mitogenicity in mouse spleen cells, pyrogenicity in rabbits, and toxic lethality in galactosamine-sensitized mice. Compared with those for enterobacterial lipopolysaccharide, mitogenicity and pyrogenicity were a thousand-fold lower and lethal toxicity was 500-fold lower. We suggest that the phosphorylation pattern and acylation in lipid A are responsible for the low biological activity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=257055Documentos Relacionados
- Typing of Helicobacter pylori with monoclonal antibodies against Lewis antigens in lipopolysaccharide.
- Activation of human THP-1 cells and rat bone marrow-derived macrophages by Helicobacter pylori lipopolysaccharide.
- Biological activities of Eikenella corrodens outer membrane and lipopolysaccharide.
- Chemical, biological, and immunochemical properties of the Chlamydia psittaci lipopolysaccharide.
- Phase Variation in Helicobacter pylori Lipopolysaccharide