Lsh, a member of the SNF2 family, is required for genome-wide methylation
AUTOR(ES)
Dennis, Kathleen
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
Methylation patterns of the mammalian genome are thought to be crucial for development. The precise mechanisms designating specific genomic loci for methylation are not known. Targeted deletion of Lsh results in perinatal lethality with a rather normal development. We report here, however, that Lsh−/− mice show substantial loss of methylation throughout the genome. The hypomethylated loci comprise repetitive elements and single copy genes. This suggests that global genomic methylation is not absolutely required for normal embryogenesis. Based on the similarity of Lsh to other SNF2 chromatin remodeling proteins, it suggests that alteration of chromatin affects global methylation patterns in mice.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=312825Documentos Relacionados
- Lsh, an SNF2/helicase family member, is required for proliferation of mature T lymphocytes
- Identification of Novel Imprinted Genes in a Genome-Wide Screen for Maternal Methylation
- Lsh, a modulator of CpG methylation, is crucial for normal histone methylation
- Genome-wide somatic hypermutation
- The catalase gene family in cucumber: genome-wide identification and organization