Lymphocyte activation by various Mycoplasma strains and species.

AUTOR(ES)

Naot, Y

RESUMO

The capacity of various mycoplasma strains and species to induce lymphocyte transformation in vitro was studied. Of six strains of Mycoplasma pulmonis studied, five displayed mitogenic activity with rat lymphocytes. Among those M. pulmonis strains, our MP15 isolate and the Negroni strain exhibited particularly potent mitogenic capacity. The murine mycoplasmas M. neurolyticum and M. arthritidis shared this mitogenicity for rat lymphocytes. However, the human mycoplasmas M. fermentans, M. pneumoniae, M. hominis, M. orale, and Acholeplasma laidlawii did not activate rat lymphocytes. Lymphocytes obtained from germfree rats were activated to the same extent as those from animals bred under conventional conditions. The mitogenic potency exhibited by mycoplasma was not restricted to infective microorganisms, and preparations of killed mycoplasma particles exerted an extensive lymphocyte transformation. The data show that the mitogenic activity of mycoplasmas is not confined to a single mycoplasma isolate and that it acts in a nonspecific manner.

Documentos Relacionados

• Differences in incorporation of nucleic acid bases and nucleosides by various Mycoplasma and Acholeplasma species.
• Detection of mixed Mycoplasma species.
• Stimulation of lymphocyte proliferation by killed mycobacteria and other bacterial species.
• Inhibition of mycoplasma-induced lymphocyte activation by sodium aurothiomalate.
• Antigenic determinants of the attachment protein of Mycoplasma pneumoniae shared by other pathogenic Mycoplasma species.