Macrophages Release Tumor Necrosis Factor Alpha and Interleukin-12 in Response to Intracellular Bacillus anthracis Spores

AUTOR(ES)

Pickering, Alison K.

FONTE

American Society for Microbiology

RESUMO

Herein we report that infection of a murine macrophage cell line with Bacillus anthracis results in the production of tumor necrosis factor alpha and interleukin-12 (IL-12). When infected with B. anthracis spores in combination with lipopolysaccharide, macrophages release increased amounts of IL-12. We found no evidence of inhibition of cytokine responses in macrophages infected with B. anthracis spores.

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