Magnitude of the fetal hemoglobin response to acute hemolytic anemia in baboons is controlled by genetic factors.
AUTOR(ES)
DeSimone, J
RESUMO
When hemolytic anemia was induced in 26 baboons (Papio cynocephalus), aged 7-22 mo, they increased their production of fetal hemoglobin (HbF). Although the resulting reduction in hematocrits and increases of reticulocyte counts were similar in all stressed animals there was marked variability in the maximal rates of HbF synthesis. The maximal levels of HbF attained appeared to fall into three separate groups: low, intermediate, and high. These differences were not related to sex or several measures of erythrocyte metabolism. Animals exposed to repeated episodes of erythropoietic stress after full hematologic recovery demonstrated some variability in their maximal HbF levels attained from one episode to another, but these variations never extended to adjacent classes. The described biochemical and mating data suggest that the magnitude of the HbF response to hemolytic anemia is controlled by genetic factors.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=371358Documentos Relacionados
- Stimulation of fetal hemoglobin synthesis in baboons by hemolysis and hypoxia.
- 5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons.
- Pathogenesis of Hemolytic Anemia in Homozygous Hemoglobin C Disease*
- ACUTE HEMOLYTIC ANEMIA FROM THE SULFONAMIDES
- Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia.