Mammalian cell function mediating recombination of genetic elements.

AUTOR(ES)

Upcroft, P

RESUMO

Recombination of segments of the SV40 genome by a variety of mechanisms is described. These include the faithful joining of linear segments that have flush termini as opposed to previously described cohesive or resected termini. Lack of involvement of viral proteins has been demonstrated for recombination of segments with homologous overlapping termini, but probably applies also to the other joining reactions. Segments of the genome that have been cleaved in such a manner as to be unable to manufacture any known viral proteins are neutral elements of genetic information, incapable of selection by replication or biological function until recombined. These recombination functions presumably are available to the host cell and any element of genetic information that can be generated in that cell.

Documentos Relacionados

• Chromosomal illegitimate recombination in mammalian cells is associated with intrinsically bent DNA elements.
• Genetic definition of ras effector elements.
• Mutant profiles of selectable genetic elements.
• Inhibition of bacteriophage replication by extrachromosomal genetic elements.
• Intramolecular recombination in polyomavirus DNA is controlled by promoter elements.