Maternal consumption of polyphenol rich foods in late pregnancy and fetal ductus arteriosus flow dynamics
AUTOR(ES)
Zielinsky, Paulo
DATA DE PUBLICAÇÃO
2010
RESUMO
Objective: To test the hypothesis that maternal consumption of polyphenol-rich foods during third trimester interferes with fetal ductal dynamics by inhibition of prostaglandin synthesis. Study Design: In a prospective analysis, Doppler ductal velocities and right-to-left ventricular dimensions ratio of 102 fetuses exposed to polyphenol-rich foods (daily estimated maternal consumption >75th percentile, or 1089 mg) were compared with 41 unexposed fetuses (flavonoid ingestion <25th percentile, or 127 mg). Result: In the exposed fetuses, ductal velocities were higher (systolic: 0.96±0.23 m/s; diastolic: 0.17±0.05 m/s) and right-to-left ventricular ratio was higher (1.23±0.23) than in unexposed fetuses (systolic: 0.61±0.18 m/s, P<0.001; diastolic: 0.11±0.04 m/s, P¼0.011; right-toleft ventricular ratio: 0.94±0.14, P<0.001). Conclusion: As maternal polyphenol-rich foods intake in late gestation may trigger alterations in fetal ductal dynamics, changes in perinatal dietary orientation are warranted.
ASSUNTO(S)
echocardiography ecocardiografia fetal clinica veterinaria ductus arteriosus prostaglandins
ACESSO AO ARTIGO
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