Measles virus fusion: role of the cysteine-rich region of the fusion glycoprotein.
AUTOR(ES)
Wild, T F
RESUMO
Measles virus (MV) fusion requires the participation of both the fusion (F) and hemagglutinin (H) glycoproteins. The canine distemper virus fusion protein (CDVF) cannot substitute for the measles virus fusion protein (MVF) in this process. Introduction of restriction enzyme sites into the cDNAs of CDVF and MVF by site-directed mutagenesis facilitated the production of chimeric F proteins which were tested for their capacity to give fusion when coexpressed with MVH. Fusion resulted when the amino-terminal half of the MVF cysteine-rich region was transferred to CDVF.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=237199Documentos Relacionados
- Localization of human platelet autoantigens to the cysteine-rich region of glycoprotein IIIa.
- Mutational analysis of the conserved cysteine-rich region of the human immunodeficiency virus type 1 Tat protein.
- Small cysteine-rich antifungal proteins from radish: their role in host defense.
- Neutralization of Hepatitis A Virus (HAV) by an Immunoadhesin Containing the Cysteine-Rich Region of HAV Cellular Receptor-1
- Importance of the cysteine-rich carboxyl-terminal half of V protein for Sendai virus pathogenesis.
