Mecillinam Susceptibility of Escherichia coli K-12 Mutants Deficient in the Adenosine 3′,5′-Monophosphate System

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RESUMO

The mecillinam resistance of Escherichia coli K-12 mutants deficient in the enzyme responsible for the synthesis of adenosine 3′,5′-monophosphate, adenylate cyclase, has been investigated. The results suggest that resistance to this antibiotic may be a consequence of the slow growth rate of these mutants rather than an intrinsic property of their genetic lesion.

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