Metabolically deficient dwarf-colony mutants of Escherichia coli: deficiency and resistance to antibiotics of strains isolated from urine culture.
AUTOR(ES)
Borderon, E
RESUMO
Sixteen metabolically deficient dwarf-colony mutants of Escherichia coli were isolated from urine culture and represented about 2% of all E. coli isolated during the same period. In 14 cases, mutants were isolated from debilitated patients: elderly persons or patients in the terminal stages of a chronic disease. In 15 of these subjects, deficient dwarf-colony mutants appeared to be the true cause of urinary tract infection, since there was leukocyturia and important bacteriuria, and organisms were obtained in pure culture. Study of metabolic deficiencies on Davis synthetic medium and nutritive agar resulted in the identification of eleven deficiencies in cysteine, two in thiamine, two in thymidine, and one in glutamine. Study of resistance to antibiotics revealed that nine were susceptible to all antibiotics, three were resistant to tetracycline alone, two were resistant to two antibiotics (chloramphenicol-tetracycline, streptomycin-tetracycline), and two were resistant to three antibiotics (ampicillin-chloramphenicol-tetracycline, ampicillin-streptomycin-tetracycline). Resistance was coded for by conjugative plasmids in five strains.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=275315Documentos Relacionados
- Recurrent Infections by a Stable Dwarf-colony Variant of Staphylococcus aureus
- Epidemiological and Biochemical Studies on Thiamine-less Dwarf-Colony Variants of Staphylococcus aureus as Etiological Agents of Bovine Mastitis
- Highly Resistant Metabolically Deficient Dwarf Mutant of Escherichia coli Is the Cause of a Chronic Urinary Tract Infection
- Mutants of Escherichia coli Sensitive to Antibiotics
- Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.