Methylprednisolone inhibits the alternative and amplification pathways of complement.

AUTOR(ES)

Weiler, J M

RESUMO

Methylprednisolone sodium succinate limited the ability of zymosan or lipopolysaccharide to activate complement in normal serum by the alternative amplification pathways. Methylprednisolone limited B consumption in a reaction mixture which contained purified C3b, D, and B, indicating that soluble steroid directly inhibited the amplification pathway. The ability of soluble steroid to inhibit events in the alternative and amplification pathways of complement may provide a partial explanation for the effectiveness of steroids in treating gram negative septic shock.

Documentos Relacionados

• Steroids inhibit activation of the alternative-amplification pathway of complement.
• Cigarette smoke can activate the alternative pathway of complement in vitro by modifying the third component of complement.
• Activation of the alternative and classical complement pathways by Entamoeba histolytica.
• Influence of serum concentration on opsonization by the classical and alternative complement pathways.
• Distinct characteristics of initiation of the classical and alternative complement pathways by Candida albicans.