Microbicidal cationic proteins in rabbit alveolar macrophages: a potential host defense mechanism.
AUTOR(ES)
Patterson-Delafield, J
RESUMO
Rabbit alveolar macrophages contain two highly cationic microbicidal proteins. These were shown to be distinct from histones and not to arise from granulocyte contamination. The macrophage proteins were especially active against Candida albicans and Candida parapsilosis. Gram-positive bacteria (Bacillus subtilis, Listeria monocytogenes, and Streptococcus faecalis) were also susceptible, whereas Escherichia coli and Salmonella typhimurium appeared more resistant. The proteins may be present in lysosomes, based on their solubilization by dilute acids and their distribution with lysosomal markers on sucrose density gradients. Such microbicidal proteins have not previously been demonstrated in any mammalian macrophage. They may play a significant role in the host-defense functions of the rabbit lung.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=551293Documentos Relacionados
- Microbicidal cationic proteins of rabbit alveolar macrophages: amino acid composition and functional attributes.
- Increased content of microbicidal cationic peptides in rabbit alveolar macrophages elicited by complete Freund adjuvant.
- Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages.
- Bactericidal mechanisms in rabbit alveolar macrophages: evidence against peroxidase and hydrogen peroxide bactericidal mechanisms.
- Human alveolar macrophages: effects of endotoxin in vitro.
