Micromonospora-Produced Gentamicin Components
AUTOR(ES)
Lee, B. K.
RESUMO
After the chromatographic separation of [methyl-14C]gentamicin major (C) components from a large-scale radioactive fermentation (Lee et al., 1974), [methyl-14C]gentamicin minor (polar) components (A, B, B1, X2, and G-418) were isolated from subsequent chromatography of the remaining antibiotic mixture. When l-[methyl-14C]methionine was added at the onset of biosynthesis of the gentamicin components, incorporation of label into the minor components preceded incorporation into the major components. Degradation occurred when [methyl-14C]gentamicin major components (C1, C2 and C1a) were added respectively to the gentamicin-producing culture medium and shaken.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=429491Documentos Relacionados
- Antibiotic G-418, a New Micromonospora-Produced Aminoglycoside with Activity Against Protozoa and Helminths: Antiparasitic Activity
- Biological Activity of Antibiotic G-418, a New Micromonospora-Produced Aminoglycoside with Activity Against Protozoa and Helminths
- Antibiotic G-418, a New Micromonospora-Produced Aminoglycoside with Activity Against Protozoa and Helminths: Fermentation, Isolation, and Preliminary Characterization
- Radioimmunoassay of gentamicin in Micromonospora medium extracts.
- Ribosomal resistance in the gentamicin producer organism Micromonospora purpurea.
