Microscopical studies of necrotising scleritis. I. Cellular aspects.
AUTOR(ES)
Young, R. D.
RESUMO
Light and electron microscopy were used to examine tissue excised during surgery from eight patients with advanced destructive scleral disease. These comprised two cases of scleromalacia perforans, three cases of anterior necrotising scleritis alone or in conjunction with other systemic diseases, and three cases in which scleritis developed following ocular surgery. It was not possible to distinguish between these three categories by histological or cytopathological criteria. All showed extensive granulomatous infiltration of the conjunctiva, episclera, and sclera by plasma cells and lymphocytes. Mast cells were abundant throughout these inflamed tissues. Examination of scleral stroma from sites in advance of the granuloma revealed active fibroblastic cells in the absence of other inflammatory cells. Fibroblastic transformation of scleral cells may be one of the earliest events in scleral degradation during necrotising disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1040470Documentos Relacionados
- Microscopical studies of necrotising scleritis. II. Collagen degradation in the scleral stroma.
- EPISCLERITIS AND SCLERITIS. I
- Use of cyclosporin in the management of steroid dependent non-necrotising scleritis.
- Mycoplasmas and "non-specific" genital infection. I. Previous studies and laboratory aspects.
- Use of orbital floor steroids in the management of patients with uniocular non-necrotising scleritis.