Minireview: Finding the Sweet Spot: Peripheral Versus Central Glucagon-Like Peptide 1 Action in Feeding and Glucose Homeostasis
AUTOR(ES)
Williams, Diana L.
FONTE
The Endocrine Society
RESUMO
Glucagon-like peptide 1 (GLP-1) is both a gut-derived hormone and a neurotransmitter synthesized in the brain. Early reports suggested that GLP-1 acts in the periphery to promote insulin secretion and affect glucose homeostasis, whereas central GLP-1 reduces food intake and body weight. However, current research indicates that in fact, GLP-1 in each location plays a role in these functions. This review summarizes the evidence for involvement of peripheral and brain GLP-1 in food intake regulation and glucose homeostasis and proposes a model for the coordinated actions of GLP-1 at multiple sites.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2703557Documentos Relacionados
- Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats.
- Differences in the Central Anorectic Effects of Glucagon-Like Peptide-1 and Exendin-4 in Rats
- The Extrapancreatic Effects of Glucagon-Like Peptide-1 and Related Peptides
- Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice
- Glucagon-like peptide-1 is a physiological incretin in rat.
