Minus-strand RNA synthesis in the spinal cords of mice persistently infected with Theiler's virus.
AUTOR(ES)
Cash, E
RESUMO
Theiler's virus, a murine picornavirus, causes a chronic neurological disease characterized by primary demyelination in SJL/J mice. The lesions are very reminiscent of those of multiple sclerosis. Theiler's virus persists in oligodendrocytes and to a lesser extent in astrocytes and macrophages throughout the disease. Viral RNA and capsid protein syntheses are minimal in these cells. This restriction could play a central role in the mechanism of virus persistence. By quantitating plus- and minus-strand RNAs in infected central nervous system cells, we showed that RNA replication was blocked at the level of minus-strand RNA synthesis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=253240Documentos Relacionados
- Synthesis of plus- and minus-strand RNA in rotavirus-infected cells.
- Restricted virus replication in the spinal cords of nude mice infected with a Theiler's virus variant.
- Specific Sindbis virus-coded function for minus-strand RNA synthesis.
- Repression and Derepression of Minus-Strand Synthesis in a Plus-Strand RNA Virus Replicon
- Short-lived minus-strand polymerase for Semliki Forest virus.