Misincorporation of 2′-deoxyoxanosine into DNA: a molecular basis for NO-induced mutagenesis derived from theoretical calculations
AUTOR(ES)
Hernández, Begoña
FONTE
Oxford University Press
RESUMO
A wide range of theoretical methods, including high level ab initio, density functional, self-consistent reaction field, molecular dynamics and thermodynamic integration calculations, have been used to analyze the mutagenic properties of oxanosine. The major tautomeric forms in the gas phase and aqueous solution have been determined. The ability of oxanosine to recognize thymine and cytosine in the gas phase and in the DNA environment has been compared with that of guanine. A physicochemical explanation for the mutagenic properties of oxanosine is suggested.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=115229Documentos Relacionados
- Antifolate-induced misincorporation of deoxyuridine monophosphate into DNA: inhibition of high molecular weight DNA synthesis in human lymphoblastoid cells.
- Formation of 2′-deoxyoxanosine from 2′-deoxyguanosine and nitrous acid: mechanism and intermediates
- Apamin inhibits NO-induced relaxation of the spontaneous contractile activity of the myometrium from non-pregnant women
- Methotrexate-induced misincorporation of uracil into DNA
- Highly specific, membrane-permeant peptide blockers of cGMP-dependent protein kinase Iα inhibit NO-induced cerebral dilation