Mitochondrial Longevity In Vitro: The Retention of Respiratory Control*

AUTOR(ES)

Romani, Roger

RESUMO

Isolated mitochondria were maintained metabolically active and coupled, i.e., capable of respiratory control, for several hours at 25°C. An increase in respiratory control generally occurred during the first 4-8 hr of incubation followed thereafter by a decline. Longevity is a dynamic function as evidenced by its dependency on substrate and cofactors, thiamine pyrophosphate, in particular. Magnesium was also essential to longevity; coenzyme A, bovine serum albumin, and reducing agents were not. The findings are discussed in terms of cytoplasmic-mitochondrial interrelationships and mitochondrial autonomy.

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