Mitotic Recombination in Yeast: Isolation and Characterization of Mutants with Enhanced Spontaneous Mitotic Gene Conversion Rates
AUTOR(ES)
Maloney, Daniel H.
RESUMO
Semi-dominant mutants displaying greatly elevated (up to 200-fold above control) levels of spontaneous mitotic recombination have been isolated in a disomic haploid strain of yeast heteroallelic at the arg4 locus. They are designated by the symbol MIC. The mutants variously exhibit associated sensitivity to UV and ionizing radiation and to methyl methanesulfonate, enhanced UV-induced mitotic recombination, and enhanced spontaneous forward mutation rates. Possible enzyme defects and involvement in repair and editing of DNA are discussed. The mutants are expected to simplify the analysis of recombination pathways in yeast.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1214183Documentos Relacionados
- Long-Tract Mitotic Gene Conversion in Yeast: Evidence for a Triparental Contribution during Spontaneous Recombination
- Spontaneous Mitotic Recombination in Yeast: The Hyper-Recombinational Rem1 Mutations Are Alleles of the Rad3 Gene
- Isolation and Characterization of Schizosaccharomyces Pombe Mutants Affected in Mitotic Recombination
- Mak mutants of yeast: mapping and characterization.
- Coincidence Relations between Gene Conversion and Mitotic Recombination in Saccharomyces